|
Turkan HalilogluProfessor in Department of Chemical EngineeringDirector of Polymer Research Center |
|
Education
1982-1987: B. S., Chemical
Engineering, Bogazici University, Istanbul.
1987-1989: M. S., Chemical Engineering, Bogazici University, Istanbul.
1989 -1992: Ph. D., Chemical Engineering, Bogazici University, Istanbul.
Research Activities
Post-Doctorate at the
University of Akron, Institute of Polymer Science,1992-1993
Visiting Scientist at the University of Akron, Institute of Polymer
Science, summers of 1994-1999
Visiting Scientist at Danold Danforth Science Center (St Louis, USA),
Department of Bioinformatics and Computational Genomics, summers of 2000, 2001
Visiting Scientist at National Cancer Institute /National Instititute of Health (Frederict, USA),
short visits, 2002-2008.
Awards
1996 Chemistry Award
(nationwide) for Young Scientists from TUBITAK (Turkish National Science and
Technology Foundation)
2000 Outstanding Achievement in Research Prize, Bogazici University
2001 Distinguished Young Scientist, Turkish Academy of Sciences
2006 Selected Associate Member, Turkish Academy of Sciences
Publications
Tozluoglu M, Karaca E, Haliloglu T, Nussinov R. Catologing and organizing p73 interactions in cell cycle arrest and apoptosis,
Nucleic Acid Res, 36, 5033-49 (2008).
Haliloglu T, Seyrek E, Erman B, “Prediction of Binding Sites in Receptor-Ligand Complex with the Gaussian Network Model”, 2008, 100 (22), 228102 (2008).
Emekli U., Scheidman-Duhovny D., Wolfson H.J., Nussinov R., Haliloglu T., “HingeProt: Automated Prediction of Hinges in Protein Structures”,
Proteins: Structure, Function, and Bioinformatics, 70, 1219-1227 (2008).
Shental-Bechor D., Haliloglu T., Ben-Tal N., “Interactions of cationic-hydrophobic peptides with lipid bilayers: A Monte Carlo simulation method”,
Biophysical Journal, 93, 1858-1871, 2007.
Ertekin A., Nussinov R., Haliloglu T., “Association of Putative Protein Binding Sites with the Fluctuation Behavior of Residues”, Protein Science,
15, 2265-2277, (2006).
Kantarci N., Doruker P., Haliloglu T., “Cooperative Fluctuations Point to the Dimerization Interface of p53 Core Domain”,
Biophysical Journal, 91, 421-432, (2006).
Ozer N., Haliloglu T., Schiffer C.A., “Substrate Specificity in HIV-1 Protease by a Biased Sequence Search Method”,
Proteins-Structure Function And Bioinformatics, 64, 444-456, (2006).
Kantarci N, Tamerler C, Sarikaya M, et al. Molecular dynamics simulations on
constraint metal binding peptides, Polymer, 46 (12), 4307-4313 (2005).
Konuklar FAS, Aviyente V, Haliloglu T, “Coupling of Structural Fluctuations to Deamidation Reaction in Triosephosphate Isomerase by Gaussian Network Model, Proteins, 62, 715-727 (2006).
Shental-Bechor D, Kirca S, Ben-Tal N, Haliloglu T, Monte Carlo Studies of
Folding, Dynamic and Stability in ?-Helices, Biophysical Journal, 88 (4):
2391-2402 (2005).
Haliloglu T, Keskin O, Ma B, Nussinov R, How similar are protein folding and
protein binding nuclei? Examination of fluctuations of energy hot spots and
conserved residues, Biophysical Journal, 88, 3, 1552-1559 (2005).
Kessel, A., Haliloglu, T., Ben-Tal, N, 'Interaction of M2d Segment of the
Acetylcholine Receptor with Lipid Bilayers: A Continuum Solvent Model Study',
Biophysical Journal, 85, 3687-3695 (2003).
Kessel, A., Haliloglu, T., Ben-Tal, N, 'Interaction of Hydrophobic Peptides
with Lipid Bilayers: Monte Carlo Simulations with M2d', Biophysical Journal,
85, 3431-3444 (2003).
Haliloglu, T, Kolinski, A, Skolnick, J, 'Use of NMR Residual Dipolar Coupling
(RDCs) as Restraints in ab initio Structure Prediction', Biopolymers, 70,
548-562 (2003).
Kurt, N., Halilogu, T, Schiffer, C, "Structure-Based Prediction of
Potential Binding and Non-Binding Peptides to HIV-1 Protease", Biophysical
Journal, 864-863 (2003).
Ozkan SB, Dalgyn GS, Haliloglu T, Unfolding events of Chymotrypsin Inhibitor 2
(CI2)revealed by Monte Carlo (MC) simulations and their consistency from
structure-based analysis of conformations, POLYMER 45 (2): 581-595 JAN 15 2004
Kurt, N., Walter, R. P. S., Schiffer, C.A., Haliloglu T., "Vibrational
dynamics of unliganded and substrate-bound HIV-1 protease: A structure-based
analysis on a variety of conformations from chrystallography and molecular
dynamics simulations", Proteins, 51, 409-422, (2003).
Kurt, N., Haliloglu, T., "Distribution of Cooperative Interactions in
Barnase at Different Time Windows by Coarse-grained simulations",Polymer,
43, 403-408 (2002).
Kurt, N, Haliloglu, T., "Conformational Dynamics of
Subtilisin-Chymotrypsin Inhibitor 2 Complex by Coarse-Grained
Simulations", Journal of Biomolecular Stucture and Dynamics, 18 (5),
713-731, (2001).
Haliloglu, T., Bahar, I., Jernigan, R. L., "Collective dynamics of class I
MHC/peptide complexes and binding to T cell receptors", Biophys. J., 78,
34A ( 2000).
Jang, J. J., Haliloglu, T., von Meerwall, E. D., and Mattice W. L.,
"Effect of Vinyl Content on Self-Diffusion in Polybutadiene Melts",
Macromolecules, 33 (11),4271-4277 (2000).
Haliloglu, T., Mattice, W. L.,"Simulation of Rotational Isomeric State Models
for Polypropylene Melts in a High Coordination Lattice", Reviews in
Chemical Engineering, 15, No:4 (1999).
Haliloglu, T., Bahar, I., "Structure-Based Characterization of Protein
Dynamics. Results for Hen Lysozyme in Comparison with X-ray Diffraction and NMR
Relaxation Data", Proteins: Structure, Function and Genetics, 37, 654-667
(1999).
Kurt, N., Haliloglu, T., "Conformational Dynamics of Chymotrypsin
Inhibitor 2 by Coarse-Grained Simulations", Proteins: Structure, Function
and Genetics,37,454-464(1999).
Haliloglu, T., "Conformational Dynamics of Cytochrome c by Coarse-Grained
Simulations, Polymer Preprints, 81, 155 (1999).
Haliloglu, T., Mattice, W. L.,"Detection of the onset of demixing in
simulations of polypropylene melts in which the chains differ only in
stereochemical composition", J. Chem. Phys., 111(9), 4327-4333 (1999).
Haliloglu, T.,"Coarse-Grained Simulations of Conformational Dynamics of
Proteins", Theoretical and Computational Polymer Science, 9/3-4, 255-260
(1999).
Haliloglu, T.,"Characterization of Internal Motions of Escherichia coli
Ribonuclease H by Monte Carlo Simulation", Proteins: Structure, Function
and Genetics, 34, 533-539 (1999).
Haliloglu, T.,Cho, J., Mattice, W. L., "Simulation of Rotational Isomeric
State Chains with Asymmetric Torsional Potential Energy Functions on a High
Coordination Lattice in Bulk State", Macromolecular Theory and
Simulations, 7, 613-617 (1998).
Haliloglu, T., Cho, J., Mattice, W. L.,"Simulation of Rotational Isomeric
State Models for Polypropylene Melts on a High Coordination Lattice",
Polymer Preprints, 78, 259-260 (1998).
Atilgan, A., Haliloglu, T., Bahar, I., Erman, B., "Correlated Fluctuations
in Polymer Networks', Theoretical and Computational Polymer Science",8,
55-59(1998).
Haliloglu, T., Mattice, W. L., "Mapping of Rotational Isomeric State
Chains with Asymmetric Torsional Potential Energy Functions on a High
Coordination Lattice. Application to Polyproplylene", J. Chem. Phys.,108,
6989-6995 (1998).
Haliloglu, T., Bahar,I.,"Coarse-Grained Simulations of Conformational
Dynamics of Proteins: Application to Apomyoglobin ", Proteins: Structure,
Function and Genetics, 31, 271-281 (1998).
Bahar, I., Erman, B., Haliloglu, T., Jernigan, R. L., "Coarse-Grained
Simulations of Collective Motions in Protein. T4 Lysozyme", Biochemistry,
36, 3512-3513 (1997).
Haliloglu, T., Bahar, I., Erman, B., 'Relative Contributions of Coupled
Rotations and Small Amplitude Torsion to Conformational Relaxation in Polymers,
Polymer Preprints, 213, 292-COMP (1997).
Haliloglu. T., Bahar, I., Erman, B., "Gaussian Dynamics of Folded
Proteins",Pysical Review Letters, 79, 3090-3093 (1997).
Haliloglu, T., Mattice, W. L., "Conformational Transitions of End-Adsorbed
triblock Copolymers in a nonselective Solvent", Macromolecular Theory and
Simulations, 6, 667-677 (1997).
Bahar, I., Doruker, P., Erman, B., Haliloglu, T., Kim, Eung-Gun, Mattice, W.
L., Monnerie, L., Rapold, R. F., " Three aproaches that may permit more
efficient simulation of the dynamics of atomistic models of polymers",
Trends in Polymer Science, 5, 155-160 (1997).
Haliloglu, T., Stevenson, D., Mattice, W. L., "Adsorption of Triblocks in
nonselective solvent", J. Chem. Phys., 106, 3365-3369 (1997).
Haliloglu, T. , Bahar, I., Erman, B. Mattice, W. L., "Relative
Contributions of Coupled Rotations and Small Amplitude Torsions to
Conformational Relaxation in Polymers", Macromolecules, 29, 8942-8947
(1996).
Haliloglu, T., Mattice, W. L., "Monte Carlo Simulation of Self-Assembly in
Macromolecular Systems", in NATO ASI , vol. 327,p.167-196, 1996, ed: S.
Webber, Kluwer.
Haliloglu, T., Bahar, I., Erman, B., "The response of a single Grafted
Chain to Shear Flow. A Brownian Dynamics Simulation Study", J. Chem.
Phys., 105, 2919-2926 (1996).
Haliloglu, T., Bahar, I., Erman, B., Mattice, W. L., "Mechanisms of the
Exchange of Diblock Copolymers between Micelles at Dynamic Equilibrium",
Macromolecules, 29, 4764-4771 (1996).
Haliloglu, T., Bahar, I., Erman, B., Kim E. -G., "A Dynamic Rotational
Isomeric State Approach for Extension of the Time Scale of the Local Dynamics
Observed in Fully Atomostic Molecular Dynamics Simulations", J. Chem.
Phys., 104, 4828-4834 (1996).
Haliloglu, T., Mattice, W. L., R The Molecular Dynamics of Poly (1,4
trans-butadieneS, Macromolecular Symposia, 101, 435-442 (1995).
Haliloglu, T., Bahar, I., Erman B., "Dependence of Segmental Orientation
on Polymer Conformational Characteristics", Polymer, 36, 4131-4134 (1995).
Haliloglu, T., Mattice, W. L., The Roles of c and N on the Dynamics of the
Exchange of Chains between Micelles Formed by Diblock Copolymers in Selective
Solvents at Concentrations Slightly Above the Critical Micelle
Concentration" , Computational Polymer Science, 5, 65-70 ( 1995).
Haliloglu, T., Mattice, W. L., "Exchange of Chains between Micelles formed
by Diblock Copolymers", ACS Polym. Prepr., 35 (1), 572-573 (1994).
Bahar, I., Erman, B., Haliloglu, T., "Role of Structural Heterogeneities
on Segmental Orientation in Deformed Chains: Applications to Alternating
Copolymers", Macromolecules, 27, 1703-1709 (1994).
Haliloglu, T., Mattice, W. L., Monte Carlo Lattice Simulation of the
Interchange of Chains between Micelles of Diblock CopolymersS, Journal of
Chemical Engineering Science, 49, 2851-2857 (1994).
Haliloglu, T., Balaji, R., Mattice, W. L., Mobility of Free Ends and Junction
Points in a Lamellar Block CopolymerS, Macromolecules, 27, 1473-1476 (1994).
Haliloglu, T., Mattice, W. L., Monte Carlo Lattice Simulation of the Exchange
Chains between Micelles of Diblock Copolymerss, ACS Polym. Prepr., 34 (2),
460-461 (1993).
Haliloglu, T., Mattice, W. L. , Analysis of Orientation Auto- and
Cross-Correlation Functions for Polyethylene in Inclusion Complex with
PerhydrotriphenyleneS, Macromolecules, 26, 3137-3142 (1993).
Haliloglu, T., Erman, B., Bahar, I., " Orientational Mobility in
Uniaxially Deformed Polymer Chains: A Brownian Dynamics Simulation Study",
Polymer, 34, 440-442 (1993).
Haliloglu, T., Erman, B., Bahar, I., " Time Dependent Probability Distribution
Functions for Orientational Motions of Segments in Polymer Chains",J.
Chem. Phys., 97, 4438-4444 (1992).
Haliloglu, T., Bahar, I., Erman, B., " Orientational and Conformational
Correlations in Deformed Polymer Chains with Fixed End-to-End Separation: A
Brownian Dynamics Simulation Study", J. Chem. Phys., 97, 4428-4437 (1992)
Haliloglu, T., Bahar, I., Erman, B., "Segmental Orientation in
Polyoxyethylene Chains", Computational Polymer Science, 1, 151-156 (1991).
Erman, B., Haliloglu, T., Bahar I., and Mark, James E., "Segmental
Orientation in Uniaxially Deformed Networks", Macromolecules, 24, 901-907
(1991).